Oncology Scan—Low-Grade Gliomas: Predicting and Changing Outcome
International Journal of Radiation Oncology * Biology * Physics
Approximately 2000 adults are diagnosed with low-grade gliomas each year in the United States . Although the World Health Organization (WHO) classification of low-grade gliomas includes both grade 1 and 2 disease, these are distinctively different entities . Grade 1 gliomas are juvenile pilocytic astrocytomas, primarily a disease of children. These typically well-circumscribed tumors are curable with gross total resection alone. In contrast, WHO grade 2 low-grade gliomas comprise diffuse astrocytomas, oligodendriogliomas, or mixed oligoastrocytomas, largely affecting older children and younger adults. Though these tumors are difficult to totally resect secondary to their infiltrative nature, median overall survival (OS) is on the order of 5-10 years. Almost inevitably these tumors recur, often transforming into higher-grade gliomas. In this article, I will discuss only WHO grade 2 low-grade gliomas in adults (LGG); high-grade gliomas have been previously discussed in an earlier Oncology Scan by Helen Shih .
Original Article: http://www.redjournal.org/article/S0360-3016(13)00538-5/abstract?rss=yes
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