Long-term outcomes of adjuvant radiotherapy after surgical resection of central neurocytoma
Radiation Oncology
Background and purposeThe role of adjuvant radiotherapy for central neurocytomas (CNs) is not clear. Therefore, we aimed to examine the clinical outcomes of treating histologically confirmed CNs with adjuvant RT after surgical resection.Material and methodsSixty-three CN patients were retrospectively evaluated: 24 patients underwent gross total resection (GTR); 28, subtotal resection (STR); 9, partial resection (PR), and 2, biopsy (Bx). They underwent adjuvant RT after surgery (median dose, 54?Gy). Results: The median follow-up was 69?months (15?129 months). The 5-year overall survival (OS) and 5-year progression-free survival (PFS) were 94.4% and 95% after GTR?+?RT, 96.4% and 100% after STR?+?RT, and 100% and 90.9% after PR?+?RT. Only three patients had tumor recurrence: at the primary site at 30 and 24?months in two GTR?+?PR patients, and dissemination to the spinal cord at 75?months in one STR?+?RT patient. Thirty-eight (63.3%) patients experienced late neurotoxicity (28, grade 1; 7, grade 2; 3, grade 3). Short-term memory impairment was the most common toxicity. Conclusions: RT after incomplete resection (IR) led to OS and PFS comparable to those for GTR. Considering the excellent outcomes and limited late toxicity, adjuvant RT maybe a good option for CN patients who undergo IR.
Original Article: http://www.ro-journal.com/content/9/1/242
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