Critical appraisal of RapidArc radiosurgery with flattening filter free photon beams for benign brain lesions in comparison to GammaKnife: a treatment planning study
Radiation Oncology - Latest Articles
Background: To evaluate the role of RapidArc (RA) for stereotactic radiosurgery (SRS) of benign brain lesions in comparison to GammaKnife (GK) based technique. Methods: Twelve patients with vestibular schwannoma (VS, n = 6) or cavernous sinus meningioma (CSM, n = 6) were planned for both SRS using volumetric modulated arc therapy (VMAT) by RA. 10MV flattening filter free photon beams with a maximum dose rate of 2400MU/min were selected. Data were compared against plans optimised for GK. A single dose of 12.5Gy was prescribed. The primary objective was to assess treatment plan quality. Secondary aim was to appraise treatment efficiency. Results: For VS, comparing best GK vs. RA plans, homogeneity was 51.7 +/- 3.5 vs. 6.4 +/- 1.5%; Paddick conformity Index (PCI) resulted 0.81 +/- 0.03 vs. 0.84 +/- 0.04. Gradient index (PGI) was 2.7 +/- 0.2 vs. 3.8 +/- 0.6. Mean target dose was 17.1 +/- 0.9 vs. 12.9 +/- 0.1Gy. For the brain stem, D1cm3 was 5.1 +/- 2.0Gy vs 4.8 +/- 1.6Gy. For the ipsilateral cochlea, D0.1cm3 was 1.7 +/- 1.0Gy vs. 1.8 +/- 0.5Gy. For CSM, homogeneity was 52.3 +/- 2.4 vs. 12.4 +/- 0.6; PCI: 0.86 +/- 0.05 vs. 0.88 +/- 0.05; PGI: 2.6 +/- 0.1 vs. 3.8 +/- 0.5; D1cm3 to brain stem was 5.4 +/- 2.8Gy vs. 5.2 +/- 2.8Gy; D0.1cm3 to ipsi-lateral optic nerve was 4.2 +/- 2.1 vs. 2.1 +/- 1.5Gy; D0.1cm3 to optic chiasm was 5.9 +/- 3.1 vs. 4.5 +/- 2.1Gy. Treatment time was 53.7 +/- 5.8 (64.9 +/- 24.3) minutes for GK and 4.8 +/- 1.3 (5.0 +/- 0.7) minutes for RA for schwannomas (meningiomas). Conclusions: SRS with RA and FFF beams revealed to be adequate and comparable to GK in terms of target coverage, homogeneity, organs at risk sparing with some gain in terms of treatment efficiency.
Original Article: http://www.ro-journal.com/content/9/1/119
Júlio Pereira
www.neurocirurgiabr.com
www.linkedin.com/in/juliommais
lattes.cnpq.br/7687651239699170
Consultório (11)3141-9550/3141-9553
No comments:
Post a Comment