[Review] Molecular neuro-oncology in clinical practice: a new horizon
The Lancet Oncology
Primary brain tumours are heterogeneous in histology, genetics, and outcome. Although WHO's classification of tumours of the CNS has greatly helped to standardise diagnostic criteria worldwide, it does not consider the substantial progress that has been made in the molecular classification of many brain tumours. Recent practice-changing clinical trials have defined a role for routine assessment of MGMT promoter methylation in glioblastomas in elderly people, and 1p and 19q codeletions in anaplastic oligodendroglial tumours.
Original Article: http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(13)70168-2/abstract?rss=yes
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