Reirradiation With Proton Therapy for Recurrent Gliomas: A Single Institution Experience
International Journal of Radiation Oncology * Biology * Physics
To evaluate the effectiveness and tolerance of re-irradiation with proton therapy (PT) in patients with recurrent gliomas. Between 2005 and 2012, 29 patients with recurrent gliomas were reirradiated with proton therapy at the Indiana University Health Proton Therapy Center. Six had low grade gliomas (LGG, WHO 1/2, median age 15.9 years), 10 grade 3 (median age 12.3 years), and 13 had glioblastoma (GBM, WHO grade 4, median age 56.7 years). The median time interval between initial radiation and reirradiation was 47.2 months for low-grade gliomas, 45.7 months for grade 3 tumors, and 15.3 months for GBMs. The median dose delivered was 54, 59.4, and 54 Gy (RBE) for the low grade, grade 3, and grade 4 tumors, respectively. 69 percent (20) of the patients were male.
Original Article: http://www.redjournal.org/article/PIIS0360301613004537/abstract?rss=yes
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