Publication date: Available online 11 May 2013
Source:Journal of Clinical Neuroscience
Author(s): Zhongzheng Jia , Daoying Geng , Ying Liu , Xingrong Chen , Jun Zhang
This study was designed to quantitatively assess the microvascular permeability of oligodendroglioma using the volume transfer constant (K trans) and the volume of the extravascular extracellular space per unit volume of tissue (V e) with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). We aimed to evaluate the effectiveness of K trans and V e in distinguishing between low-grade and anaplastic oligodendroglioma. The maximal values of K trans and V e for 65 patients with oligodendroglioma (27 grade II, 38 grade III) were obtained. Differences in K trans and V e between the two groups were analysed using the Mann-Whitney rank-sum test. Receiver operating characteristic (ROC) curve analyses were performed to determine the cut-off values for the K trans and V e that could differentiate between low-grade and anaplastic oligodendrogliomas. Values for K trans and V e in low-grade oligodendrogliomas were significantly lower than those in anaplastic oligodendrogliomas (p <0.001 and p <0.001, respectively). ROC curve analysis showed that cut-off values of the K trans (0.037min−1) and V e (0.079) could be used to distinguish between low-grade and anaplastic oligodendrogliomas in a statistically significant manner. Our results suggest that DCE-MRI can distinguish the differences in microvascular permeability between low-grade and anaplastic oligodendrogliomas.
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