Available online 19 February 2013
Publication year: 2013
Source:World Neurosurgery
Objective For the rarity incidence, patients with esophageal cancer metastasized to the central nervous system have rarely reported. The aim of our study was to assess the frequency of brain metastasis from primary esophageal cancer, and to detect the clinical characteristics, diagnosis and prognosis. Methods A retrospective analysis of the medical files was carried out in a series of 26 consecutive patients with central nervous system involvement treated at our institution between 2000 and 2010 from 1612 esophageal primary carcinoma. The clinical history, image, and pathologic findings were analyzed. Results Among the 26 patients, 12 initially presented with a single cerebral metastatic lesion, and 14 had multiple brain lesions. There were 4 patients with adenocarcinoma, 22 with squamous cell carcinoma. Five of them received surgery followed with whole brain radiation, 5 underwent stereotactic radiosurgery, and 13 received whole brain radiation, 3 patients received chemotherapy treatment. The median survival period was 4.2 months, one year survival rate was 5.8%. Conclusions This retrospective study of 1612 patients with esophageal carcinoma at a single medical centre, indicated that 1.61% (26/1612) of these patients had a diagnosis of brain metastasis. The prognosis is poor for the brain metastasis of esophageal carcinoma. Solitary brain lesion, surgery and good KPS may indicate a well prognosis.
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