In this edition's Oncology Scan, I have chosen to focus attention on a common problem in the world of radiation oncology—the frail, elderly patient with glioblastoma for whom the most appropriate management has been poorly defined. I have selected 3 recent, high-quality studies, 2 of them randomized trials, that shed new light on the care of patients with this disease and that point us in new directions. Six weeks of radiation therapy, which has been the standard management choice for decades, is now being challenged either by abbreviated radiation treatment or by temozolomide alone. Radiation oncologists would be well advised to stay abreast of this rapidly changing landscape.
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