Hypofractionated stereotactic radiotherapy and continuous low-dose temozolomide in patients with rec

Abstract  

To evaluate the efficacy of reirradiation and systemic chemotherapy as salvage treatment in patients with recurrent malignant glioma. Between May 2006 and December 2011, 54 patients with recurrent malignant glioma received hypofractionated stereotactic radiotherapy (HSRT) plus systemic therapy at University of Rome Sapienza, Sant' Andrea Hospital. All patients had Karnofsky performance score ≥60 and were previously treated with standard conformal RT (60 Gy) with concomitant and adjuvant temozolomide (TMZ) up to 12 cycles. Thirty-eight patients had a GBM and 16 patients had a grade 3 glioma. The median time interval between primary RT and reirradiation was 15.5 months. At the time of recurrence all patients received HSRT (30 Gy in 6-Gy fractions) plus concomitant TMZ (75 mg/m²/day) followed by continuous TMZ at 50 mg/m² everyday up to 1 year or until progression. Median overall survival after HSRT was 12.4 months, and the 12- and 24-month survival rates were 53 and 16 %, respectively. The median progression-free survival (PFS) was 6 months, and the 12- and 24-month PFS rates were 24 and 10 %, respectively. KPS >70 (P = 0.04) and grade 3 glioma were independent favourable prognostic factors for survival. In general chemoradiation regimen was well tolerated with relatively low treatment-related toxicity. HSRT plus concomitant TMZ followed by continuous dose-intense TMZ is a feasible treatment option associated with survival benefits and low risk of complications in selected patients with recurrent malignant glioma. The potential advantages of combined chemoradiation schedules in patients with recurrent malignant gliomas need to be explored in future studies.

• Content Type Journal Article
• Category Clinical Study
• Pages 1-8
• DOI 10.1007/s11060-012-0999-9
• Authors
  • Giuseppe Minniti, Department of Radiation Oncology, Sant' Andrea Hospital, University Sapienza, Rome, Italy
  • Claudia Scaringi, Department of Radiation Oncology, Sant' Andrea Hospital, University Sapienza, Rome, Italy
  • Vitaliana De Sanctis, Department of Radiation Oncology, Sant' Andrea Hospital, University Sapienza, Rome, Italy
  • Gaetano Lanzetta, Department of Neurological Sciences, IRCCS Neuromed, Pozzilli (IS), Italy
  • Teresa Falco, Department of Radiation Oncology, Sant' Andrea Hospital, University Sapienza, Rome, Italy
  • Domenica Di Stefano, Department of Pathology, Sant' Andrea Hospital, University Sapienza, Rome, Italy
  • Vincenzo esposito, Department of Neurological Sciences, IRCCS Neuromed, Pozzilli (IS), Italy
  • Riccardo Maurizi Enrici, Department of Radiation Oncology, Sant' Andrea Hospital, University Sapienza, Rome, Italy

• Journal Journal of Neuro-Oncology
• Online ISSN 1573-7373
• Print ISSN 0167-594X

http://www.springerlink.com/content/60l671u778185l1x/

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