Abstract
Among glioma treatment strategies, antiangiogenesis emerges as a meaningful and feasible treatment approach for inducing long-term survival. Isthmin is a gene highly expressed in the isthmus of the midbrain–hindbrain organizer in Xenopus, and has recently been identified as a novel angiogenesis inhibitor. However, the potential of isthmin on the glioma angiogenesis has not been well studied. In the present study, we demonstrated that the recombinant adenovirus isthmin (Ad-isthmin) could inhibit VEGF-stimulated endothelial cell proliferation and induce apoptosis through a caspase-dependent pathway. In addition, Ad-isthmin significantly suppressed glioma growth through antiangiogenesis without apparent side effects. Taken together, our results demonstrated that isthmin could act as a novel angiogenesis inhibitor and might be utilized in the glioma antiangiogenesis therapy.
- Content Type Journal Article
- Category Laboratory Investigation
- Pages 1-8
- DOI 10.1007/s11060-012-0910-8
- Authors
- Bangqing Yuan, Department of Neurosurgery, The 476th Hospital of Fuzhou General Hospital, Fuzhou, 350025 Fujian, China
- Ronghua Xian, Department of Neurosurgery, The 476th Hospital of Fuzhou General Hospital, Fuzhou, 350025 Fujian, China
- Jianfang Ma, Department of Neurosurgery, The 476th Hospital of Fuzhou General Hospital, Fuzhou, 350025 Fujian, China
- Yujian Chen, Department of Neurosurgery, The 476th Hospital of Fuzhou General Hospital, Fuzhou, 350025 Fujian, China
- Chuangan Lin, Department of Neurosurgery, The 476th Hospital of Fuzhou General Hospital, Fuzhou, 350025 Fujian, China
- Yaoming Song, Department of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037 China
- Journal Journal of Neuro-Oncology
- Online ISSN 1573-7373
- Print ISSN 0167-594X
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