1P19Q loss but not IDH1 mutations influences WHO grade II gliomas spontaneous growth

Abstract  

Mutations at the codon 132 in the isocitrate dehydrogenase 1 (IDH1) gene occur early, with a high frequency, in World Health Organization (WHO) grade II gliomas. We investigated the impact of IDH1 mutations on spontaneous glioma growth rate, known to be an early prognostic factor.The mean tumor diameter was assessed on the first MRI performed at diagnosis and on a second MRI, performed immediately before surgery, in a series of 64 WHO grade II gliomas. The patients did not undergo treatment before surgery. Because of a frequent association, we jointly analyzed the 1p19q co-deletion and IDH1 mutations effects on tumor velocity of diameter expansion (mm/year) during preoperative spontaneous growth period. 1p19q co-deletion had a significant slowing effect (p = 0.0133) on tumor growth estimated at −1.7760 ± 0.711 mm/year (95% CI −3.154, −0.366), whereas IDH1 mutations estimated effect of +0.036 ± 0.833 mm/year (95% CI −1.668; +1.596) was not significant (p = 0.9654). Our results provide first evidence that IDH1 mutations are not significantly involved in tumor growth rate. By contrast, we confirm that 1p19q co-deletion decreases growth velocity.

• Content Type Journal Article
• Category Laboratory Investigation
• Pages 1-7
• DOI 10.1007/s11060-012-0831-6
• Authors
  • Catherine Gozé, Laboratoire de Biologie Cellulaire et Hormonale CHU de Montpellier, 371 Avenue Doyen Giraud, 34295 Montpellier Cedex 5, France
  • Charlotte Bezzina, Laboratoire de Biologie Cellulaire et Hormonale CHU de Montpellier, 371 Avenue Doyen Giraud, 34295 Montpellier Cedex 5, France
  • Eric Gozé, CIRAD, UPR SCA, 34398 Montpellier, France
  • Valérie Rigau, Centre des Collections Biologiques Hospitalières de Montpellier (CCBH-M), CHU de Montpellier, 34295 Montpellier Cedex 5, France
  • Thierry Maudelonde, Laboratoire de Biologie Cellulaire et Hormonale CHU de Montpellier, 371 Avenue Doyen Giraud, 34295 Montpellier Cedex 5, France
  • Luc Bauchet, INSERM U1051 Institut des Neurosciences de Montpellier, 80 rue Augustin Fliche, BP 74103 34291, Montpellier Cedex 5, France
  • Hugues Duffau, INSERM U1051 Institut des Neurosciences de Montpellier, 80 rue Augustin Fliche, BP 74103 34291, Montpellier Cedex 5, France

• Journal Journal of Neuro-Oncology
• Online ISSN 1573-7373
• Print ISSN 0167-594X

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