Medulloblasoma: challenges for effective immunotherapy

Abstract  

For medulloblastoma patients, the current therapeutic paradigm of surgery followed by radiation and chemotherapy can lead to long-term remission. However, the sequelae of treatment can be very debilitating, particularly in young children. Immunotherapy is an attractive treatment approach to optimize the targeting of tumor cells while sparing the vulnerable surrounding brain that is still developing in children. Understanding the relationship between medulloblastoma and the immune system is critical to develop effective immunologic-based treatment strategies for these patients. This review focuses on current knowledge of tumor immunology and the factors that contribute to the lack of immune system recognition of these tumors. The specificity of tumor antigens present in medulloblastoma is also discussed along with a summary of early clinical immunotherapy results.

• Content Type Journal Article
• Category Topic Review
• Pages 1-10
• DOI 10.1007/s11060-011-0776-1
• Authors
  • Adam M. Sonabend, Department of Neurological Surgery, Neurological Institute, New York Presbyterian Columbia University, 710 West 168th Street, New York, NY 10032, USA
  • Alfred T. Ogden, Department of Neurological Surgery, Neurological Institute, New York Presbyterian Columbia University, 710 West 168th Street, New York, NY 10032, USA
  • Lisa M. Maier, Department of Neurological Surgery, Neurological Institute, New York Presbyterian Columbia University, 710 West 168th Street, New York, NY 10032, USA
  • David E. Anderson, Department of Neurological Surgery, Neurological Institute, New York Presbyterian Columbia University, 710 West 168th Street, New York, NY 10032, USA
  • Peter Canoll, Department of Neurological Surgery, Neurological Institute, New York Presbyterian Columbia University, 710 West 168th Street, New York, NY 10032, USA
  • Jeffrey N. Bruce, Department of Neurological Surgery, Neurological Institute, New York Presbyterian Columbia University, 710 West 168th Street, New York, NY 10032, USA
  • Richard C. E. Anderson, Department of Neurological Surgery, Neurological Institute, New York Presbyterian Columbia University, 710 West 168th Street, New York, NY 10032, USA

• Journal Journal of Neuro-Oncology
• Online ISSN 1573-7373
• Print ISSN 0167-594X

http://www.springerlink.com/content/1648603865504775/

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