Publication year: 2011
Source: World Neurosurgery, Available online 23 November 2011
Ivan Ciric
Pituicytomas are rare sellar-suprasellar tumors, largely benign, that are of glial origin. They usually present with symptoms related to their location: headaches, visual changes and mostly anterior pituitary dysfunction. Imaging diagnosis reveals a sellar-suprasellar lesion occupying the position of the stalk. The characteristic histological features are spindle cell tumors arranged in storiform pattern. The immunohistochemical analysis of the tissue is characterized by strong immunopositivity for glial fibrilary acidic protein (GFAP) signifying their glial origin and for nuclear staining with thyroid transcription factor-1 (TTF-1) signifying their origin from pituicytomas.The preferred treatment is gross total surgical removal since there is no evidence that adjuvant therapy is effective. Incomplete resections lead to recurrences.
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