Cerebral pleomorphic xanthoastrocytoma associated with NF1: an updated review with a rare atypical c

Abstract  

The occurrence of cerebral pleomorphic xanthoastrocytoma (PXA) in individuals with neurofibromatosis type 1 (NF1) is very rare. We present a 10-year-old Nigerian boy with NF1 who was found to harbor a thalamic-lateral ventricular solid mass lesion whose histologic and immunohistochemical findings were in keeping with PXA. We also carried out an updated review of the PXA-NF1 literature and found only eight previous reports of this clinical disease association. These reports have been limited to only certain regions of the world, with none yet reported from Africa, South America, Australia, and Eastern Europe. As far as we know, this might be the first such report from Africa. The case we present, in addition, demonstrated some other unique clinical, radiological, and histopathologic characteristics which have been highlighted in this review.

• Content Type Journal Article
• Category Review
• Pages 1-7
• DOI 10.1007/s10143-011-0362-1
• Authors
  • Amos O. Adeleye, Division of Neurological Surgery, Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria
  • Clement A. Okolo, Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria
  • Effiong E. Akang, Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria
  • Adekunle M. Adesina, Department of Pathology, Baylor University College of Medicine, Houston, TX, USA

• Journal Neurosurgical Review
• Online ISSN 1437-2320
• Print ISSN 0344-5607

http://www.springerlink.com/content/l59m321k8xq923h7/

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Júlio Leonardo B. Pereira

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